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The research found almost 50% of women who used oral fluconazole in the first 6 months of pregnancy were more likely to have a miscarriage than the women who did not use the drug. In 2011, the US Food and Drug Administration changed the pregnancy category of oral fluconazole from C to D — except for use for thrush. This followed several reports of birth defects in babies whose mothers had been treated with high-dose fluconazole (400-800 mg/day). The women had serious and life-threatening fungal infections during the first trimester. Pregnancy category D means there is positive evidence of risk to human fetuses based on human data. However, doctors may decide to accept these risks in serious or life threatening situations due to the potential benefits from use of the drug. - See more at: http://www.bellybelly.com.au/pregnancy/thrush-treatment-linked-to-miscarriage/
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