| 4:36 AM
While the females got pregnant
The research found almost 50% of women who used oral fluconazole in the first 6 months of pregnancy were more likely to have a miscarriage than the women who did not use the drug. In 2011, the US Food and Drug Administration changed the pregnancy category of oral fluconazole from C to D — except for use for thrush. This followed several reports of birth defects in babies whose mothers had been treated with high-dose fluconazole (400-800 mg/day). The women had serious and life-threatening fungal infections during the first trimester. Pregnancy category D means there is positive evidence of risk to human fetuses based on human data. However, doctors may decide to accept these risks in serious or life threatening situations due to the potential benefits from use of the drug. Treatments For Thrush Vaginal and topical anti-fungal creams are usually the first-line treatment for pregnant women with thrush. Despite the lack of safety information about oral fluconazole, the drug is often prescribed for thrush during pregnancy, especially if the infection is recurring. A single dose of 150mg is considered by the FDA to be safe for use by women and has a pregnancy category C. It’s believed that at this level there is no increased risk of birth defects in babies. Yet the Danish study showed women who were on the single 150mg dose were still at increased risk of miscarriage. Women on higher doses had a greater risk. Oral fluconazole-exposed pregnancies in the group were compared with up to four unexposed pregnancies matched by calendar year, maternal age and gestational age. - See more at: http://www.bellybelly.com.au/pregnancy/thrush-treatment-linked-to-miscarriage/
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